Pathogenetic mechanisms of excess weight

Pathogenetic mechanisms of excess weight — screening

Why it matters

The tendency to gain weight can vary considerably from person to person. Nutrition, physical activity, hormonal and metabolic factors, as well as genetics, can all play a role. Inherited genetic variants may be associated with differences in appetite and satiety, fat accumulation, glucose regulation and energy metabolism. Genetic screening therefore gives the physician additional information about mechanisms that may contribute to weight gain.

The results are assessed alongside laboratory findings, body composition, medical history and the patient’s lifestyle. This approach helps identify the areas that require particular attention and supports a more personalised weight

The link between genetics and weight gain

Genes can influence appetite, satiety, adipose tissue function and metabolism. The screening analyses MC4R, PPARG, FTO, INS and PPARGC1B, which are associated with different mechanisms involved in body weight regulation. The test helps identify inherited characteristics that may increase the tendency to gain weight. The physician can use these findings when developing an individual strategy for weight loss and long-term weight management.

Genetic factors and weight management

Excess weight can develop under the influence of nutrition, insufficient physical activity, hormonal and metabolic factors, and inherited characteristics. Obesity, in turn, may contribute to the development of insulin resistance, type 2 diabetes and cardiovascular disease, as well as increase the risk of musculoskeletal problems. If excess weight returns after weight loss or losing weight is more difficult than expected, it is important to assess the possible causes comprehensively. Genetic screening helps identify inherited characteristics associated with key mechanisms of body weight regulation. Together with laboratory testing, these findings help the physician gain a deeper understanding of metabolic disorders and determine individual areas for further weight management.

Genetic predisposition to excess weight and obesity

Inherited characteristics of appetite regulation

Tendency to accumulate body fat

Characteristics of carbohydrate and lipid metabolism

Genetic factors associated with insulin activity

Characteristics of energy metabolism

Additional data for personalised weight management

Excess weight and obesity

Family history of excess weight

Increased appetite and difficulty controlling eating behaviour

Weight regain after weight loss

Insulin resistance

Metabolic syndrome

Disorders of carbohydrate and lipid metabolism

Assessment of risk factors for type 2 diabetes

Development of an individual weight loss strategy

Nutrition and physical activity planning

Long-term weight management

Programme components

The screening includes 5 genes associated with key mechanisms of body weight regulation. Their combined assessment provides the physician with essential information about inherited characteristics of eating behaviour, adipose tissue function, and carbohydrate and energy metabolism.

Pathogenetic mechanisms of excess weight – screening – section on genetic risk factors for metabolic disorders

3 000 AED

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Pathogenetic mechanisms of excess weight — screening