Peptide LL-37 is an endogenous cathelicidin with a broad spectrum of antimicrobial activity. It plays an important role in maintaining skin health by improving its barrier functions and accelerating the wound healing ...
Peptide LL-37 is an endogenous cathelicidin with a broad spectrum of antimicrobial activity. It plays an important role in maintaining skin health by improving its barrier functions and accelerating the wound healing process. Additionally, LL-37 has moderate anti-inflammatory properties, making it an effective agent for treating various skin diseases.
LL-37 — an endogenous cathelicidin (37 amino acids, hCAP-18 fragment), a powerful antimicrobial peptide of the immune system with a broad-spectrum effect on bacteria, viruses, fungi, and biofilms.
Properties and mechanism
LL-37 destroys microbial membranes (amphiphilic α-helix), neutralizes LPS (endotoxins), modulates immunity: neutrophil/monocyte chemotaxis, mast cell degranulation, angiogenesis, and wound healing.
It improves the skin barrier (hydration, epithelium regeneration), reduces inflammation (IL-6, TNF-α), stimulates blood vessel growth; dual role in oncology (apoptosis or proliferation).
|
Area |
Effects |
|---|---|
|
Infections |
Chronic (staph/candida), sepsis, long COVID |
|
Immunity |
Leaky gut, autoimmunity (psoriasis ↓) |
|
Regeneration |
Wounds/burns x2-3, acne, colitis |
|
Anti-age |
Inflammation ↓, skin/gut |
Trends 2026
Dermatology/immunity: Top 10 in post-procedural therapy (Refresh Clinic: LL-37 + BPC-157); combo with antibiotics against resistance; nanoforms for acne.
Improves the skin barrier (hydration, epithelium regeneration), reduces inflammation (IL-6, TNF-α), stimulates blood vessel growth; dual role in oncology (apoptosis or proliferation).
LL-37 — Innate Immunity N1 for Skin and Infections
The LL-37 peptide is an important component of the human immune system. Its antimicrobial properties and ability to regulate inflammation make it a promising candidate for the development of new medicinal drugs.
|
Stack |
Effect |
Dose LL-37 + partner |
|---|---|---|
|
LL-37 + BPC-157 |
Wounds + infections x4 |
100+250 mcg |
|
LL-37 + TB-500 |
Skin/ligaments |
150+500 mcg |
|
LL-37 + GHK-Cu |
Regen + immunity |
100 mcg + 1 mg |
|
LL-37 + Vit D |
LL-37 ↑500% |
100 mcg + 5000 IU |
The use of the LL-37 peptide is indicated for conditions such as acne and skin infections. It is also widely used in post-procedural rehabilitation, helping the skin recover faster after various cosmetic procedures. Due to its unique properties, LL-37 is a valuable component in the arsenal of dermatologists and cosmetologists, contributing to improved skin condition and enhanced protective functions.
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