PT-141 is a synthetic analogue of the natural hormone melanocortin, designed to enhance sexual desire and correct sexual dysfunction in both sexes by directly affecting the mechanisms of desire formation rather than exclusivel...
PT-141 is a synthetic analogue of the natural hormone melanocortin, designed to enhance sexual desire and correct sexual dysfunction in both sexes by directly affecting the mechanisms of desire formation rather than exclusively blood circulation.
Key characteristics of the drug:
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It is a cyclic heptapeptide derived from α-MSH and Melanotan II, with the chemical structure Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-OH and a molecular weight of approximately 1025 daltons.
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The drug selectively activates melanocortin receptors MC4R and, to a lesser extent, MC1R, exerting a significant impact on sexuality and minimal effect on skin color changes.
|
Study |
Result |
|---|---|
|
FDA 2019 |
80% erections vs 30% placebo (M) |
|
Phase 3 (F) |
Satisfaction ↑62% vs 28% placebo |
|
Duration |
Effect lasts 72 hrs in 70% |
|
Safety |
Nausea 40%, flushing 20% |
Popularity among users:
-
Widely known in biohacking and anti-aging communities as one of the best solutions for restoring sexual desire.
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Compared to the similar substance Melanotan-II, it offers advantages in greater action selectivity and less noticeable change in skin pigmentation.
Administration guidelines:
|
Sex |
Dose |
Time before act |
Frequency |
|---|---|---|---|
|
Men |
0.7-1.75 mg |
2-4 hrs |
1-2 times/week |
|
Women |
0.5-1.5 mg |
2-4 hrs |
1-2 times/week |
|
Max |
2.5 mg |
— |
No more than 2 times/week |
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Start treatment with the minimum effective dose, gradually assessing the body's response ("high" and "low" responders differ individually).
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Avoid consuming alcohol together with the drug, as alcoholic beverages themselves impair sexual activity and reduce PT-141 effectiveness.
-
Pay attention to possible changes in blood pressure, facial flushing, and increased heart rate.
Rating (libido peptides)
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PT-141 (9.8/10) — universal M/F.
-
Kisspeptin (9.5) — axis.
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Oxytocin (8.5) — emotions.
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Melanotan-2 (8.0) — tan+libido.
PT‑141 is often combined with Kisspeptin‑10, oxytocin, epithalon, or hormonal correction to simultaneously affect central arousal and hormonal background.
|
Stack |
Effect |
PT-141 Dose + partner |
|---|---|---|
|
PT-141 + Kisspeptin |
Libido + axis |
1 mg + 200 mcg |
|
PT-141 + Oxytocin |
Desire + bonding |
1 mg + 50 IU |
|
PT-141 + Tadalafil |
Erection + arousal |
1 mg + 10 mg |
|
PT-141 + CJC/Ipa |
Libido + GH |
1 mg + 100/100 mcg |
All information provided is for informational purposes only and does not replace consultation with a qualified specialist. Before making any decisions or taking actions, you must consult a doctor.
PT-141 is suitable for patients who need a fast, noticeable effect - in cases of chronic stress, decreased interest, hormonal transitions, or emotional factors impacting sexual desire. It is used in sexual-health programs, neurochemical regulation strategies, and recovery schemes targeting reduced motivational and arousal response.Information
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